NFKB1 and diffuse large B-cell lymphoma: For example, a greater understanding of the pathophysiologic processes of PT-DLBCL shows that 60% to 96% of cases were activated B-cell-like (ABC) subtype in cell of origin23,24, the adverse prognosis by which may be attributed to chronic active B-cell receptor signaling and constitutive NF-κB and PI3K activation25.