MKI67 and neoplasm: Compared with those who had IPI (<2), intrathecal prophylaxis, and 5-hmC reduction <80%, patients with IPI (≥2), no intrathecal prophylaxis, or 5-hmC reduction ≥80% had worse 5-year OS by Cox univariate analysis (P < 0.05), while there was no significant difference on OS among different groups of age at diagnosis (> 60 vs. ≤ 60, P = 0.215), LDH (normal/abnormal, P = 0.619), testicular lymphoma involvement (unilateral or bilateral, P = 0.121), Ki-67(≥ 90% vs. < 90%, P = 0.665) and tumor diameter((≥7.5 vs. <7.5cm, P =0.930).