According to the results of cytoscape, the targets of JFBDS for treating COVID-19 mainly contained EGFR, PIK3CA, lymphocyte-specific protein tyrosine kinase (LCK), mitogen-activated protein kinase 1 (MAPK1), MAPK3, MAPK8, STAT3, TNF, IL2 and RELA. The gene discussed is PIK3CA; the disease is COVID-19.