Given the importance of the degree of type I/III IFN response in disease progression1,7,10,12,15,33, we use it in our modelling to reproduce the mild case and both the early and late stages of severe cases of COVID-19, as well as an uninfected control, through setting key input nodes in the model (see Fig. 2b and Supplementary Table 3). This evidence concerns the gene IFNA1 and COVID-19.