A higher dietary PRAL was significantly associated with migraine-related disability, as shown by HIT-6, in subjects of the third tertile compared to those in the first tertile, either in the crude model (β = 2.28; 95% CI 0.17, 4.39) or after controlling for age, sex and energy intake (β = 2.42; 95% CI 0.13, 4.70). This evidence concerns the gene PRAL and migraine disorder.