PFKFB3 and acute lymphoblastic leukemia: Given that miRs are reported to affect glycolysis level by targeting the genes coding glycolysis rate-limiting enzymes, such as PFKFB3 [16], GLUT-1 [17], and PFK1 [18], we reported that impaired miR-652-5p could slow the cell growth of T-ALL in vitro and prolong the survival time in vivo.