NF-κB activation under this condition has been analyzed via immunofluorescence staining of activated p65 in biopsies, which clearly indicated both the activation and the expression of NF-κB within the mucosal macrophages and epithelial cells of patients with IBD Notably, a significant correlation between activation NF-κB number and intestinal inflammation severity has been observed [8]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.