Moreover, in the DSS-induced IBD mouse model, METTL3 knockdown partially ameliorated DSS-induced intestinal injury and inflammation, as manifested as increased body weight and decreased DAI scores, decreased MPO, NO, and MDA, and reduced IL-1β, TNF-α, IL-6, IL-18, COX-2, and iNOS. This evidence concerns the gene METTL3 and inflammatory bowel disease.