Chen et al. designed PEGylated liposome-polycation-DNA (LPD) nanoparticles and obtained LPD-PEG-NGR by modifying the NGR peptide targeting tumor-specific receptor aminopeptidase N. LPD-PEG-NGR delivered siRNA into solid tumors in mice with systemic, specific, and effective delivery, and by delivering c-myc siRNA, it effectively triggered the apoptosis of tumor cells by down-regulating the expression of c-myc, thus inhibiting the growth of some tumors393. This evidence concerns the gene MYC and neoplasm.