Furthermore, P62-RIPK1-RIPK3-dependent necroptosis contributes to aging-related myocardial vulnerability to I/R injury and sorafenib induces DU145 prostate cancer cells death by exploring the association of P62 and RIPK1 via immunoprecipitation or a proximity ligation assay [24, 25]. Here, RIPK1 is linked to prostate cancer.