FBXL17 (lead SNP:rs552690895; p = 2.5E-08) was associated with cIMT in the combined dataset analysis and is linked to cardiovascular physiology through its involvement in protein degradation where it plays a central role in cardiovascular physiology and disease: from endothelial function, the cell cycle, atherosclerosis, myocardial ischaemia, cardiac hypertrophy, inherited cardiomyopathies and heart failure. The gene discussed is FBXL17; the disease is cardiac hypertrophy.