Moreover, our exploration of other potential brain “insulinopathies” yielded evidence for global genetic overlap of ADHD, AN, MDD, and SCZ with somatic insulin-related diseases/traits, while genetic covariance at the level of insulin-related gene sets was identified between ADHD, AN, BD, SCZ and T2DM/MetS/obesity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.