In the prenatal restraint stress (PRS)-induced depression rat model, icariin relieves PRS-induced depressive-like behavior accompanied by a decrease in excitatory amino acid transporter 2 (EAAT2), metabotropic glutamate receptor 1 and 5 (mGluR1 and mGluR5) expressions in the hippocampus [14]. The gene discussed is GRM1; the disease is major depressive disorder.