The phosphorylation of Akt plays a vital role in the PI3K/Akt signaling pathway [158, 159], it regulates various substrates, such as GSK-3β, Bcl-2 [160] and is involved in the pathogenesis of different brain diseases, including AD [161], epilepsy [162], and cerebral ischemia [163]. The gene discussed is AKT1; the disease is brain ischemia.