Nitrogen permease regulator-like 2 (NPRL2) is a requisite subunit of the epilepsy-linked GAP activity toward Rags 1 (GATOR1) complex that functions as a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) kinase when intracellular amino acids are limited. This evidence concerns the gene NPRL2 and epilepsy.