NPRL2 and epilepsy: As genetic studies have identified >700 mutations in genes that code for voltage-gated sodium channels in epilepsy (Kaplan et al., 2016), and reports of GATOR1 and Scn1A mutations contributing to temporal epilepsy (Baldassari et al., 2016), our data now implicate the NPRL2 and mTORC1 regulatory pathways in controlling Scn1a expression.