For example, a reduction in the dopaminergic tone and the expression of D2R are observed in women suffering from polycystic ovary syndrome (Chaudhari et al., 2018) and the secretion of luteinizing hormone (LH) is sensitive to D2/3R antagonist in prepubertal females (Lacau de Mengido et al., 1987). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.