The Effect of Perioperative Anti-HER2 therapy on Early Breast Cancer Study – Biological phase (EPHOS-B) was designed to assess whether either single-agent lapatinib or trastuzumab given as perioperative treatment had effects on Ki67 and/or apoptosis compared with no anti-HER2 therapy prior to surgery (part 1). Here, MKI67 is linked to breast carcinoma.