Of note, co-chaperones DNAJA1 and DNAJB6 have previously been identified as modulators of poly-Q huntingtin (htt) aggregation in a cellular Huntington’s disease model, with the knock-out (KO) of DNAJB6 resulting in a fivefold increase in poly-Q74htt aggregation while a DNAJA1 KO resulted in a fourfold decrease of poly-Q74htt aggregation [79]. This evidence concerns the gene HTT and Huntington disease.