NBN and acute lymphoblastic leukemia: In the present study, we investigated the influence of polymorphisms within XRCC1 (rs1799782 G > A) and NBN (rs1805794 C > G, rs709816 A > G) genes on susceptibility to childhood ALL in a sample of the Iranian population by HRM analysis as a powerful, cost-effective and practicable method [31, 32] for detecting SNVs and discriminating the wild type and mutant genotypes with melting temperature shifts more than 0.4 °C [33].