While a number of previous studies have already indicated the potential importance of CTNND2/WNT-signaling in EAC [27], a potentially more striking observation is that deletion of CTNND1 has been shown to lead to esophageal squamous cell carcinoma (ESCC) development [28, 29]. The gene discussed is CTNND2; the disease is esophageal squamous cell carcinoma.