In this regard and considering the important individual roles of TXNIP and GLUT1 in diabetes susceptibility and the direct interplay of both genes in glucose metabolism [17–20], we evaluated the interaction between the genetic variant (GLUT1 rs841853) and the epigenetic aberration (TXNIP cg19693031 methylation) on the fasting blood glucose levels of Taiwanese without type 2 diabetes. The gene discussed is TXNIP; the disease is diabetes mellitus.