Following the identification of the vital functions of hub genes in the network, 18 hub genes (CCND2, STAT3, TP53, MCL1, MYC, FOXO1, FOXO3, BCL2L11, PTEN, MTOR, CDH1, CASP3, IL6, GSK3B, CDKN1A, MAPK1, SMAD4, CDC42) were identified in GC using the MCODE plugin, MCODE_Score = 13.76. This evidence concerns the gene CASP3 and gastric cancer.