Our findings indicated that, METTL14 suppressed GC growth by increasing the m6A level of circORC5 and decreasing its expression, and circORC5 sponged miR-30c-2-3p and upregulated ElF4B and AKT1S1, contributing to GC tumorigenesis (Fig. 9). The gene discussed is AKT1S1; the disease is gastric cancer.