AKT1S1 and gastric cancer: In conclusion, our findings demonstrate that downregulation of METTL14 was associated poor survival in patients with GC, and METTL14-mediated m6A modification of circORC5 inhibits growth and invasion of GC cells by regulating miR-30c-2-3p/AKT1S1 axis and may provide a promising prognostic factor for GC.