ESR1 and cancer: A variety of different types of cancer have already been described as having an increased risk when associated to excessive body fatness, such as cancers from the gastrointestinal tract (esophagus, cardia, stomach, pancreas, gallbladder, liver, colon, rectum), breast (postmenopausal, specifically ER+ breast cancer risk, whereas ER− or TNBC is little or inversely associated with obesity), kidney, thyroid, prostate, ovary, endometrium, multiple myeloma, and meningioma [135, 136].