Additionally, Gibson and colleagues also investigated the effect of obesity on MDSC-mediated immunotherapy resistance in a breast cancer mouse tumor model, showing that obesity could trigger the accumulation of FasL+ granulocytic MDSCs, inducing apoptosis of tumor-infiltrating CD8 T lymphocytes and immunotherapy resistance in this cancer [395]. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.