Also highlighting the impact of diet on MS development, high-fat diet (HFD) mouse models display exacerbated VAT inflammation [102] due to the action of saturated FFAs on NLRP3 [103], and Toll-like receptors-2 (TLR-2) and 4 (TLR-4) [104]. This evidence concerns the gene TLR2 and myeloid sarcoma.