Notably, hsa_circ_0087960 (derived from LPAR1, hereafter termed circLPAR1) was the only circRNA to be validated in cell lines with significantly downregulated expression in colorectal cancer cells (HCT116 and DLD1) compared with normal FHC cells (Fig. 1H and Fig. S1A-B). The gene discussed is LPAR1; the disease is colorectal cancer.