Among the 57 types, esophageal adenocarcinoma (44.83%), serous ovarian cancer (40.41%) and uterine serous carcinoma (36.7%) had the highest frequency of GSDM genes alteration, while chromophobe renal cell carcinoma (1.54%), pheochromocytoma (1.36%) and acute myeloid leukemia (0.5%) had the lowest. The gene discussed is GSDMA; the disease is chromophobe renal cell carcinoma.