Intrahepatic cholangiocarcinoma, cutaneous melanoma, uterine endometrioid carcinoma and uterine mixed endometrial carcinoma had the highest GSDMA (6.67%), GSDMB (2.7%), GSDME (6.52%) and PJVK (4.76%) mutation frequency, respectively. This evidence concerns the gene GSDMB and intrahepatic cholangiocarcinoma.