We first measured cytokine secretion from isolated IEC cells, and the results showed that maternal diabetes (STZ/WT) significantly increased cytokine secretion of IL1β (see Fig. 7a), IL6 (see Fig. 7b), MCP1 (see Fig. 7c) and IL17A (see Fig. 7d) compared to CTL/WT group; RORA deficiency (RORA−/−), including treatments of CTL/RORA−/− and STZ/RORA−/−, either mimicked or worsened this effect. The gene discussed is IL1B; the disease is diabetes mellitus.