The results showed that maternal diabetes (STZ/VEH) treatment significantly deceased the mRNA levels of RORA, CYP19A1 and SOD2 (P < 0.0001), respectively, compared to the CTL/VEH group; SOD mimetic MnTBAP treatment (STZ/MnTBAP) completely reversed this effect; while RORA agonist (STZ/SR1078) completely reversed the expression of CYP19A1, partly reversed on SOD2 (P < 0.01), but showed no effect on RORA (see Fig. 1a). This evidence concerns the gene RORA and diabetes mellitus.