We then evaluated oxidative stress, and the results showed that maternal diabetes (STZ/WT) significantly increased ROS formation (see Fig. 6d) and 3-nitrotyrosin formation (see Fig. 6e), respectively, compared to the CTL/WT group; RORA deficiency (RORA−/−) either mimicked or worsened this effect. This evidence concerns the gene RORA and diabetes mellitus.