CASP3 and acute myeloid leukemia: As comparison to the siRNA-NC group, TUNEL analysis showed more TUNEL-positive AML-193 cells in siRNA-RAB27B group, together with downregulated anti-apoptotic Bcl2 expression and pro-apoptotic Bax, cleaved caspase 3 and cleaved PARP expression (Figure 3c-d).