It was previously suggested that spike complex N-glycans are important for infection, since MGAT1 knockout HEK293 cells were partially protected against spike-pseudotyped vesicular stomatitis virus (12), spike fusion proteins produced in MGAT1 knockout cells bound less effectively to ACE-2 (12), and most spike N-glycans are hybrid or complex typed (39, –, 41). The gene discussed is ACE2; the disease is infection.