In skeletal myopathy patients, Unger et al. [166] reported an up-regulation of HSPB5 and HSPB1 (HSP27) in myopathic versus control muscles with the massive binding of HSPB5, HSPB1, and HSPC1 (HSP90) proteins to the sarcomeric I-band region of the altered myofibers. This evidence concerns the gene CRYAB and Skeletal myopathy.