IAPP and type 2 diabetes mellitus: Similarly, using β-cell-specific human IAPP transgenic mice, Singh and colleagues showed a significant acceleration of severe diabetic symptoms and accumulation of Th-S-positive amyloid-laden plaques in the pancreas of aged mice compared to the younger littermates despite comparable hIAPP protein levels [33], indicating contribution of co-precipitation factors in hIAPP aggregation and likely islet amyloidosis in T2D subjects.