These include huntingtin implicated in Huntington’s disease, α-synuclein implicated in Parkinson’s disease, prion protein implicated in Creutzfield–Jacob’s disease, superoxide dismutase implicated in amyotrophic lateral sclerosis, amyloid-β (Aβ) peptide implicated in Alzheimer’s disease, transthyretin implicated in transthyretin familial amyloidosis and Tau implicated in frontotemporal lobar degeneration. This evidence concerns the gene SNCA and Alzheimer disease.