CHST3 and cancer: Furthermore, the combination of HSD with K858 and 41 markedly emphasizes the antiproliferative effect, whereas the combination of HSD with 2 underlines an effective control of the signalling involved in angiogenesis occurrence, leading to hypothesize that Eg5 inhibitors, even if showing a similar chemical structure, intervene and regulate different molecular cascades, thus representing an innovative strategy in the development of anti-cancer therapeutic protocols.