SLC2A1 and Alzheimer disease: Postmortem studies in individuals with AD have demonstrated a decrease in GLUT1 and GLUT3, especially in the parietal, frontal, temporal, and occipital cortices, the caudate nucleus, and the hippocampus [127,128,129]—coincidentally the same brain regions that demonstrate glucose hypometabolism in FDG-PET studies [127] (Figure 1B).