Brain-permeable, cell-membrane-passable, mitochondrially targeted antioxidant agents, such as Mn(III) meso-tetrakis(N-n-butoxyethyl-pyridinium-2yl)porphyrin, MnTnBuOE-2-PyP5+—also known as BMX-001 or MnP (an MnSOD mimetic) [404]—and mito-Tempol (a mitochondrially directed antioxidant), have shown promise in attacking certain ROS-associated cancers and other disorders [405]. This evidence concerns the gene SOD2 and cancer.