TP53 and malignant colon neoplasm: In addition, JKA97 also showed significant apoptotic activity against another human colon cancer cell line with p53 mutations (SW-620).Srinivas et al. (2009) synthesized amid alkaloids which were characterized as (4R,5R)-2E-4,5-dihydroxy-1-(piperidin-1-yl)dec-2-en-1-one 68 and (4R,5R)-2E-4,5-dihydroxy-N-isobutyloct-2-enamide 69 [108].