A review by Hatziagapiou K et al. summarized the anti-AD mechanism of Crocus sativus L., including the following: antioxidative stress, inhibitory effects of Aβ fibrillogenesis, inhibitory effects of tau aggregation, reduction of glutamatergic synaptic transmission, restoration of cellular antioxidant defenses, and inhibition of cellular apoptosis or death [134]. This evidence concerns the gene MAPT and Alzheimer disease.