TRAF6 and COVID-19: In contrast, FBA elicited an up-regulation of the genes involved in expression in the Toll-like receptor (TLR) signaling pathway, an innate immune system targeting viruses: CHUK, an inhibitor of Nf-kB [27]; Adam17, a metallopeptidase involved in the shedding of ACE2 [28]; TRAF6, a negative regulator of cytokine storms [29]; interferon regulatory factor-7 (Irf7), which is inhibited in the gastrointestinal tract of COVID-19 patients [30].