Variations in SOD2 activity are found during different cell cycle stages [40,41,42]; and an argument for a TSG role can be made based on studies showing reduced SOD2 expression in pancreatic cancer cells, as well as glioma cells, and SOD2 results showing significantly delayed tumor cell growth in nude mice xenograft studies [43,44]. Here, SOD2 is linked to familial pancreatic carcinoma.