Since epidermal growth factor receptor (EGFR) is a key mediator in the regulation of different important cellular processes [49,50] and its overexpression displays a significant role in the development of many human cancers, including hepatic cancer and breast cancer [51,52], it was of interest to examine the EGFR inhibition activities of the compounds that revealed the most potent cytotoxic activities, as one of their cytotoxic mechanisms of action. Here, EGFR is linked to liver cancer.