EGFR and cancer: Since epidermal growth factor receptor (EGFR) is a key mediator in the regulation of different important cellular processes [49,50] and its overexpression displays a significant role in the development of many human cancers, including hepatic cancer and breast cancer [51,52], it was of interest to examine the EGFR inhibition activities of the compounds that revealed the most potent cytotoxic activities, as one of their cytotoxic mechanisms of action.