NPM1 and acute myeloid leukemia: For these patients, the strong TLR4 responses showed no independent association with prognosis whereas variations between patients in the generally weaker TLR1/2 responses showed a significant association with favorable prognosis that was independent of karyotype, NPM1 insertion, FLT3 internal tandem duplication, and etiology (i.e., secondary AML versus de novo).