The effect of TLR4 targeting on MSCs/osteoblasts seems to depend on the biological context (Section 5.1 and Section 5.2); due to the functional heterogeneity of AML cells with regard to their constitutive protein release the biological context/microenvironment of the osteoblasts and thereby the effect of TLR4 targeting will differ between AML patients [25,35,45,112,113,114,115,116]. The gene discussed is TLR4; the disease is acute myeloid leukemia.