For these patients, the strong TLR4 responses showed no independent association with prognosis whereas variations between patients in the generally weaker TLR1/2 responses showed a significant association with favorable prognosis that was independent of karyotype, NPM1 insertion, FLT3 internal tandem duplication, and etiology (i.e., secondary AML versus de novo). The gene discussed is TLR4; the disease is acute myeloid leukemia.