ABCB1 and Familial prostate cancer: Multidrug resistance protein 1 (MDR1), one of the ATP-binding cassette transporters responsible for drug efflux, resides in lipid rafts in prostate cancer cell lines [749], and the inhibition of flotillins—scaffolding proteins that are key components in lipid rafts—was shown to reverse MDR in colon cancer cell lines [750].