The fact that PrPC enhances clinical resistance to cisplatin in colorectal cancer cell [88] and increases invasiveness and resistance to doxorubicin-induced apoptosis in LS 174T colon cancer cells [89] supports the theory that PrPC serves important physiological functions [5] including antioxidant protection [90]. The gene discussed is PRNP; the disease is malignant colon neoplasm.