Experimental results showed that PrPC may act as an ancillary protein that is required for the function and expression of GLUT1 where PrPC depletion inhibited glucose utilization in human colorectal carcinoma cell lines and a human colorectal xenograft model in nude mice, with significant reductions in proliferation and survival of cancer cells both in vitro and in vivo [598]. Here, PRNP is linked to colorectal carcinoma.