PGP and neoplasm: Therefore, in the case of multi-disease combination, there will be interactions between drugs, such as P-gp [25,26], which has a variety of inducers in vivo, including antibacterial drug rifampicin, anti-tumor drug vincristine, doxorubicin, cardiovascular drug verapamil [27], hyperlipidemia drug atorvastatin [28], etc., which can induce the overexpression of P-gp in vivo.