IFITM2 and pancreatic ductal adenocarcinoma: Recently, a high level of BAG3 has been detected in the serum of pancreatic ductal adenocarcinoma (PDAC) suffering patients, where it interacts with the transmembrane receptor IFITM-2 (interferon-induced transmembrane protein 2), located on macrophages surface, producing the inhibition of IL-6 cellular release [17].