Indeed, BAG3 is over-expressed in several neoplastic cell types and solid tumors including breast cancer, human hepatocellular carcinoma (HCC), glioblastomas, and pancreatic adenocarcinomas, where its high expression levels are correlated with a poor prognosis [8,9,10,11,12,13,14,15,16]. This evidence concerns the gene BAG3 and hepatocellular carcinoma.