In ischemic stroke model, MG was able to limit progression of brain damage by downregulating the NF-κB pathway; preventing IκB-α degradation and NF-κBp65 translocation that led to suppression of proinflammatory markers’ (TNF-α, phospho-ERK p42/44, p-selectin, iNOS, MMP-9 (matrix metalloproteinases-9)) expression. Here, MMP9 is linked to ischemic stroke.