CCN2 and congestive heart failure: In doxorubicin-induced CHF, SFN increased Nrf2 gene expression and transcriptional activity (NQO-1, HO-1) as well as inhibited the expression of inflammatory factor plasminogen activator inhibitor-1 (PAI-1) and fibrotic factor, connective tissue growth factor (CTGF) [134,154,155].