NFKB1 and atherosclerosis: SFN suppressed both development and progression of atherosclerosis as shown in hypercholesterolemic rabbits: it improved endothelial function (i.e., aortic relaxation and normalized intima/media (I/M) ratio) probably through its antioxidant (normalized aortic nitrate and serum antioxidants), anti-inflammatory (lowered C-reactive protein (CRP) and lactate dehydrogenase (LDH), decreased NF-κB expression), and anti-lipidemic (normalized serum lipids) effects [150].