NPPA and congestive heart failure: With regards to chronic heart failure (CHF) induced with aortic constriction in rabbits, SFN for 12 weeks led to the suppression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), reduction of collagen I and collagen III expression in heart tissues (which decreases cardiac fibrosis) resulting in improved cardiac function and remodeling [63].