In models of obesity, AITC reduced body weight, blood glucose, serum TG, and fat accumulation by inhibiting adipocyte differentiation through downregulating adipogenic transcription factors (C/EBPα, C/EBPβ, PPARγ, LPL (lipoprotein lipase), FAS, aP2 (adipocyte protein 2), and adipsin), galectin-12 expression, and adipokine expression (leptin and resistin). Here, LPL is linked to obesity due to melanocortin 4 receptor deficiency.