For example, Regmier et al. [32] and Montagner et al. [33] reported that in PPARα deficient HFD mice, body weight, serum TG, GOT and GPT, liver inflammation, liver steatosis and other obesity related index would be significantly higher than control group, which indicated the importance of PPARα in lipid metabolism. This evidence concerns the gene PPARA and obesity due to melanocortin 4 receptor deficiency.