CASP8 and lung cancer: In a similar study from Yu et al. [9], they revealed that Ova induces the apoptosis of lung cancer cell lines A549 and H1299 through both intrinsic and extrinsic pathways characterized by elevated PUMA, Bax and DR5 proteins, decreased Bcl-2 and Mcl-1 and activated caspase-8, caspase-9 and caspase-3.