HAMP and IRIDA syndrome: Heeney et al. reported an AUC of 0.886 for the TSAT/log10(hepcidin) ratio to differentiate between biallelic affected IRIDA patients and wild-type IDA controls with a specificity of 89% (95% CI, 75–95%) at a fixed sensitivity of 80% and a cut-off value of <4.0%/ng per mL (i.e., <1.43%/nM; molecular weight of hepcidin-25: 2.789 kDa) [13].