In addition, TSAT/hepcidin ratios were significantly lower in biallelic versus monoallelic affected IRIDA patients (p = 0.021; Table 3; Figure 2c), and in male and premenopausal female IRIDA patients compared to their IDA counterparts (p = 0.002 and p < 0.001, respectively; Table 3). The gene discussed is HAMP; the disease is IRIDA syndrome.