Indeed, Chronic Obstructive Pulmonary Disease (COPD) [17], various types of cancer [16], diabetes [23], and Non-Alcoholic Fatty Liver Disease (NAFLD) [24,25], strongly associated with type II diabetes [26,27], are conditions associated with both high AKR1B10 expression and a high proportion of severe COVID-19 forms. This evidence concerns the gene AKR1B10 and COVID-19.