To investigate the role of AKR1B10 on inflammatory processes and particularly on the induction of the cytokine storm, we overexpressed AKR1B10GFP in a murine macrophage cancerous cell line and in a human non-small cell lung carcinoma cell line (respectively, RAW264.7 and H1299) and tested the inflammatory response of the cells by monitoring the mRNA expression of three different cytokines (IL-6, TNFα and IL-1β) known to be involved in the cytokine storm. The gene discussed is TNF; the disease is non-small cell lung carcinoma.