Over expression of AKR1B10GFP [1 μg] in H1299 lung cancer cells (Figure 3B) induces similar effects but with a lower order of magnitude for IL-6 and IL-1β (respectively, 3-fold change from control, p < 0.01 and 1.5-fold change from control, p < 0.05) than those observed in macrophages, and no significant modification of TNFα expression (1.1-fold change from control, ns). The gene discussed is TNF; the disease is lung cancer.