Given the clinical relevance of constitutive activation of the KEAP1-NRF2 axis in NSCLC [22], we also performed NRF2 downregulation experiments in two lung adenocarcinoma cell lines, A549 and H460, which have high NRF2 basal levels due to missense and truncating mutations in KEAP1. This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.