KEAP1 and lung adenocarcinoma: Given the clinical relevance of constitutive activation of the KEAP1-NRF2 axis in NSCLC [22], we also performed NRF2 downregulation experiments in two lung adenocarcinoma cell lines, A549 and H460, which have high NRF2 basal levels due to missense and truncating mutations in KEAP1.