TRPV4 and breast cancer: TRPV4 was also found to be overexpressed in some basal breast cancers and in cell lines like the human-derived triple-negative metastatic adenocarcinoma MDA-MB-468 [28], where its potent activation via GSK1016790A selective agonist, was shown to induce cell death, such effect was reduced in cells with silenced expression of TRPV4 and absent in cells lines with decreased levels of expression or absence [28].