In this context, Cabrera et al. showed that tumor-secreted NRG1 stimulates macrophages to express JAG1 (jagged canonical Notch ligand 1), which in turn might activate Notch-associated signaling on endothelial cells, thereby promoting angiogenesis as well as on tumor cells leading to increased transendothelial migration and invasion [65]. Here, NRG1 is linked to neoplasm.