Among all genes included in these categories (Figure 4D), we would like to highlight several interesting candidates involved in angiogenesis (PTGS2, SLIT2, JAG1, RECK, and BMPER), cytoskeleton reorganization (MISP, FSCN1, and DLC1), and/or tumor cell migration and motility (PTGS2, JAG1, PDGFD, MISP, HES1, NRG1, ITGB3, DOCK10, GPC6, FSCN1, DACH1, RHOU, RECK, and DLC1). The gene discussed is MISP; the disease is neoplasm.