Perioperative administration of lidocaine in a BC murine model of surgery, during sevoflurane anaesthesia, reduced the metastatic burden of lung tissue but not the hepatic colonies.No statistical differences were found in serum VEGF and IL-6 concentrations between groups 4 weeks after perioperative administration.Lidocaine infusions were stopped before the postoperative period, presenting a study limitation. The gene discussed is IL6; the disease is breast cancer.