Lidocaine inhibited proliferation, migration, and invasion of BC cell line MCF-7 by modulating the MicroRNA-495-3p/Fibroblast Growth Factor 9 axis.The overexpression of FGF9 inhibited the inhibitory effect of lidocaine on the proliferation, migration, and invasion of breast cancer MCF-7 cells. The gene discussed is FGF9; the disease is breast carcinoma.