KCNQ1OT1 and cancer: However, treatment with LPS (6 μg/μL) increased SASP factor (IL-1β, IL-6, and MMP3) expression in human cancer cells; additional treatment with pcDNA3.1-KCNQ1OT1 (36,181–37,140) abrogated the LPS-mediated induction of SASP factors (Figure 3B).