We suggest that GCs improve the DBA pathology via at least four relatively independent ways: (i) induction of BFU-E cell proliferation via stress erythropoiesis, (ii) (de)regulation of P53 signalling, (iii) deactivation of c-Myc, and (iv) inhibition of mTOR signalling. Here, MYC is linked to Diamond-Blackfan anemia.